Serum Cytokeratin 19 Fragment, CK19-2G2, as a Newly Identified Biomarker for Lung Cancer
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چکیده
منابع مشابه
Serum Cytokeratin 19 Fragment, CK19-2G2, as a Newly Identified Biomarker for Lung Cancer
BACKGROUND CK19-2G2, a new fragment of cytokeratin 19, is a potential tumor marker for diagnosing lung cancer. The preoperative level of serum CK19-2G2 has been demonstrated to be associated with tumor metastasis and survival of breast cancer patients. This study investigated the postoperative dynamic changes in serum CK19-2G2 levels and its clinical significance in lung cancer patients. MATE...
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INTRODUCTION Lung cancer is one of the most lethal malignancies; however, no serum marker has been routinely recommended until now. METHODS THIS IS A PROSPECTIVE CASE CONTROL STUDY INCLUDING TWO GROUPS OF PATIENTS: Group I-patients with advanced lung cancer and Group II-patients with benign lung disease as control. Serum cytokeratin 19 (CK19) fragment levels were measured at baseline by real-...
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BACKGROUND This study focused on the association between preoperative serum carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (Cyfra 21-1) levels and pathologic parameters in patients with resected non-small-cell lung cancer (NSCLC). MATERIALS AND METHODS The records of 527 patients who underwent pulmonary resection of NSCLC were reviewed. The association between preoperative serum C...
متن کاملSerum fragment of cytokeratin subunit 19 measured by CYFRA 21-1 immunoradiometric assay as a marker of lung cancer.
Cytokeratin 19 is a subunit of cytokeratin intermediate filament expressed in simple epithelia and their malignant counterparts. Therefore, it is expressed by respiratory epithelium cells and has been detected in lung cancer specimens. An immunoradiometric assay was used to detect a fragment of the cytokeratin 19, referred to as CYFRA 21-1, in the serum of 165 patients with histologically prove...
متن کاملSerum cytokeratin 18 fragment level as a noninvasive biomarker for non-alcoholic fatty liver disease.
BACKGROUND AND AIM We evaluated the usefulness of serum cytokeratin 18 fragment (CK18-F) as a noninvasive biomarker in differentiating nonalcoholic steatohepatitis (NASH) from nonalcoholic fatty liver (NAFL) since the prognosis of the 2 diseases differ. METHODS 116 Japanese patients with nonalcoholic fatty liver disease (NAFLD) proven by liver biopsy were studied. Histological findings were c...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0101979